transvaginal perfusion of g-csf for infertile women with thin endometrium in frozen et program: a non-randomized clinical trial
نویسندگان
چکیده
background: we often see patients with a thin endometrium in art cycles, in spite of standard and adjuvant treatments. improving endometrial growth in patients with a thin endometrium is very difficult. without adequate endometrial thickness these patients, likely, would not have reached embryo transfer. objective: we planned this study to investigate the efficacy of intrauterine granulocyte colony-stimulating factor (g-csf) perfusion in improving endometrium, and possibly pregnancy rates in frozen-thawed embryo transfer cycles. materials and methods: this is a non-randomized intervention clinical trial. among 68 infertile patients with thin endometrium (-7 mm) at the 12th-13th cycle day, 34 patients received g-csf. g-csf (300 microgram/1ml) to improve endometrial thickness was direct administered by slow intrauterine infusion using iui catheter. if the endometrium had not reached at least a 7-mm within 48-72 h, a second infusion was given. endometrial thickness was assessed by serial vaginal ultrasound at the most expanded area of the endometrial stripe. results: the cycle was cancelled in the patients with thin endometrium (endometrial thickness below 7mm) until 19th cycle day ultimately the cycle cancelation rate owing to thin endometrium was similar in g-csf group (15.20%), followed by (15.20%) in the control group (p=1.00). the endometrial growth was not different within 2 groups, an improvement was shown between controlled and g-csf cotreated groups, with chemical (39.30% vs. 14.30%) and clinical pregnancy rates (32.10% vs. 12.00%) although were not significant. conclusion: our study fails to demonstrate that g-csf has the potential to improve endometrial thickness but has the potential to improve chemical and clinical pregnancy rate of the infertile women with thin endometrium in frozen-thawed embryo transfer cycle
منابع مشابه
Transvaginal perfusion of G-CSF for infertile women with thin endometrium in frozen ET program: A non-randomized clinical trial
BACKGROUND We often see patients with a thin endometrium in ART cycles, in spite of standard and adjuvant treatments. Improving endometrial growth in patients with a thin endometrium is very difficult. Without adequate endometrial thickness these patients, likely, would not have reached embryo transfer. OBJECTIVE We planned this study to investigate the efficacy of intrauterine granulocyte co...
متن کاملP-81: G-CSF Intrauterine and Thin Endometrium, and Pregnancy Outcome, Non Randomized Clinical Trial
Background Is G-CSF has any effects on cancelled ART cycle due to thin endometrium. This study showed the beneficial effects of G-CSF on thin endometrium. In two previous studies, some beneficial effects were reported and in another no effects were seen. MaterialsAndMethods In a nonrandomized clinical trial, fifteen cases were evaluated from June 2011 till September 2012. All cases had history ...
متن کاملg-csf intrauterine for thin endometrium, and pregnancy outcome
objective: to evaluate effects ofg-csf on a cancelled art cycle due to thin endometrium. materials and methods: in a nonrandomized clinical trial from january 2011 to january 2013 in two tertiary university based hospitals fifteen patients undergoing embryo transfer and with the history of cycle cancellation due to thin endometrium were studied. intrauterine infusion of g-csf was done on the da...
متن کاملG-CSF Intrauterine for Thin Endometrium, and Pregnancy Outcome
OBJECTIVE To evaluate effects of G-CSF on a cancelled ART cycle due to thin endometrium. MATERIALS AND METHODS In a nonrandomized clinical trial from January 2011 to January 2013 in two tertiary university based hospitals fifteen patients undergoing embryo transfer and with the history of cycle cancellation due to thin endometrium were studied. Intrauterine infusion of G-CSF was done on the d...
متن کاملP-108: Efficacy of Intrauterine Injection of Granulocyte Colony Stimulating Factor on Treatment of Unexplained Recurrent Miscarriage
Background Effects of GCSF (Granulocyte Colony-stimulating Factor) injection in patients suffering from recurrent pregnancy loss has been studied in some studies and we now know that transvaginal perfusion of G-CSF might be helpful for improvement of implantation rate among patients with thin endometrium and patients under in vitro fertilization /embryo transfer (IVF/ET) or intracytoplasmic spe...
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عنوان ژورنال:
international journal of reproductive biomedicineجلد ۱۲، شماره ۱۰، صفحات ۶۶۱-۰
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